The IRI-DICE hypothesis: ionizing radiation-induced DSBs may have a functional role for non-deterministic responses at low doses

Window theory in non-ionizing radiation-induced adaptive responses.

Do Low Doses of Ionizing Radiation Affect the Human Brain?

The aim of this paper is to analyze the current evidence on radiocerebral effects following exposure to <5 Sv. Dose-related cognitive and neurophysiological abnormalities among prenatally exposed children after the Chernobyl accident at gestation ages of +8 weeks were revealed at >20 mSv on the fetus and >300 mSv on the thyroid in utero; at 16–25 weeks, abnormalities were >10 mSv and >200 mSv, ...

Will radiation-induced bystander effects or adaptive responses impact on the shape of the dose response relationships at low doses of ionizing radiation?

Radiation induced bystander effects and adaptive responses are two phenomena that modulate cellular responses to low doses of ionizing radiation. Bystander effects generally exaggerate the effects of low doses of radiation by eliciting detrimental effects in nonirradiated cells, thus making the target for radiation effects greater than the volume irradiated. Adaptive responses on the other hand...

Alzheimer ’s Disease: Possible Mechanisms Behind Neurohormesis Induced by Exposure to Low Doses of Ionizing Radiation

In 2016, scientists reported that human exposure to low doses of ionizing radiation (CT scans of the brain) might relieve symptoms of both Alzheimer’s disease (AD) and Parkinson disease (PD). The findings were unbelievable for those who were not familiar with neurohormesis. X-ray stimulation of the patient’s adaptive protection systems against neurodegenerative diseases was the mechanism pr...

Estimating cancer risks from low doses of ionizing radiation.

Disagreements about the somatic risks from low doses of ionizing radiation stem from two difficulties fundamental to the logic of inference from observational data. First, precise direct estimation of small risks requires impracticably large samples. Second, precise estimates of low-dose risks based largely on high-dose data, for which the sample size requirements are more easily satisfied, mus...